Dorohedoro takes place between two worlds -- in a city so miserable it’s only referred to as “the Hole” and a dimension of Sorcerers that freely use the citizens of the Hole as guinea pigs for horrible experiments in black magic. Like the manga, the show has one hell of an opening hook: A giant, gyoza-obsessed man named Caiman (voiced by Wataru Takagi, best known as Okuyasu of JoJo’s Bizarre Adventure), working as an orderly in a dystopian world of magic, is cursed with a lizard head by an unknown sorcerer, losing his memories in the process. On top of that, there’s an angry-looking man living inside the back of his throat. To determine who did this to him, Caiman bites on sorcerers’ heads to talk to that man, who says if they “are not the one.” And so in their off-hours, he and his best friend Nikaido, an expert martial artist and gyoza chef, hunt and kill the sorcerers in the Hole, hoping that eventually they’ll nab the right one.