Homunculus (Japanese: ホムンクルス, Hepburn: Homunkurusu) is a Japanese manga series written and illustrated by Hideo Yamamoto. It was serialized in Shogakukan's seinen manga magazine Weekly Big Comic Spirits from March 2003 to February 2011, with its chapters collected in 15 tankōbon volumes. A live-action film adaptation, directed by Takashi Shimizu and starring Gō Ayano premiered in April 2021.