Brother and Sister (French: Frère et Sœur) is a 2022 French drama film directed by Arnaud Desplechin, starring Marion Cotillard and Melvil Poupaud as estranged siblings who are forced to reunite after two decades following the death of their parents. The film made its world premiere at the 2022 Cannes Film Festival where it competed for the Palme d'Or, and was released in theaters in France on the same day as its Cannes premiere, on 20 May 2022.