Sheldon tries to use the conundrum of Schrödinger's Cat (used to illustrate the Copenhagen Interpretation of Quantum Physics) to reflect the state of the relationship between Penny and Leonard. The cat was placed in a box with a vial of poison that would open at a random time. From the outside, no one could know whether the cat was dead or alive until they actually opened the box, and until that happened, the cat could be thought of as BOTH dead AND alive. Sheldon points that to Penny that until she and Leonard actually DO date, their relationship and the outcome of dating can be interpreted as both good and bad.
S01E17 The Tangerine Factor episode.

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