Horizontal lines and the new RS design package in black with rock gray contrasting seams dominate the interior of the RS5 models. The strongly contoured RS sport seats can be set electrically in many ways; their armrests are embossed with the RS logo. As standard, a mixture of Alcantara and leather with a honeycomb pattern serves as upholstery material; fine Nappa leather is available on request. As a new feature in RS5 models, the inlays are available in carbon matt.

The future-oriented interior design harmonizes with the new operating concept, which is concentrated on a 10.1-inch MMI touch display. This is based on the new third-generation modular infotainment platform (MIB 3). The large display, which is equipped with acoustic feedback, stands freely in the space and is slightly tilted toward the driver. Its menu structure is simple and intuitive like that of a smartphone. The natural-language voice control understands many formulations from everyday speech.