Dr. Sandra Lee, better known as Dr. Pimple Popper, sees all sorts of people who have various skin ailments. She never knows who will come in on any given day and what she will need to do in order to help them fix their problems. Cheri and Janice are two sisters who have possibly matching lumps. While Cheri is a true popaholic, Janice is grossed out by the whole situation. Will she be able to handle hers and her sister's bump extractions?