Benjamin Franklin invented a radically new arrangement of the glasses in 1761 after seeing water-filled wine glasses played by Edmund Delaval at Cambridge in England in May 1761. Franklin worked with London glassblower Charles James to build one, and it had its world premiere in early 1762, played by Marianne Davies.

Writing to his friend Giambatista Beccaria in Turin, Italy, Franklin wrote from London in 1762 about his musical instrument: "The advantages of this instrument are, that its tones are incomparably sweet beyond those of any other; that they may be swelled and softened at pleasure by stronger or weaker pressures of the finger, and continued to any length; and that the instrument, being well tuned, never again wants tuning. In honour of your musical language, I have borrowed from it the name of this instrument, calling it the Armonica."