'Deadpool 2' Knocks Off 'Avengers: Infinity War' For Top Box Office Spot The Ryan Reynolds-led movie brought in an estimated $125 million in the domestic box office, with another $176 million expected internationally. This means that ‘Deadpool 2’ made around $300 million worldwide in its first weekend, though it wasn’t able to beat its predecessor’s domestic record of $132.4 million, the highest opening weekend ever for an R-rated film. The first two incarnations of ‘Deadpool’ now own the top two spots for the biggest opening weekends by R-rated films.