Prostate cancer androgen deprivation therapy
- 6 years ago
Today, CancerBro will explain what is prostate cancer deprivation therapy.
Video Transcript:
The next treatment modality is androgen deprivation therapy. For this, we first have to understand the hormonal axis causing the testosterone release.
Pituary gland releases LH and FSH, which directly acts on the testis to release testosterone.
ACTH released from pituitary gland acts on the adrenal gland to release DHEA, which subsequently gets converted into testosterone.
The testosterone released from testis and adrenal gland enters the prostate cell and gets converted into DHT which causes the growth and survival of prostate cancer cells.
We can block this pathway, to reduce the action of testosterone on prostate cancer cells. GNRH agonists or antagonists prevents the release of LH, FSH and ACTH from pituitary gland.
Then come the cytochrome 17P inhibitors that prevent the release of testosterone from testis and adrenal gland. And finally there are androgen receptor blockers that prevents the binding of testosterone to prostate cancer cells, thereby preventing it's action.
Another method for androgen deprivation is surgical castration in which both testes are removed. Unlike medical constration it is a one time procedure.
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Video Transcript:
The next treatment modality is androgen deprivation therapy. For this, we first have to understand the hormonal axis causing the testosterone release.
Pituary gland releases LH and FSH, which directly acts on the testis to release testosterone.
ACTH released from pituitary gland acts on the adrenal gland to release DHEA, which subsequently gets converted into testosterone.
The testosterone released from testis and adrenal gland enters the prostate cell and gets converted into DHT which causes the growth and survival of prostate cancer cells.
We can block this pathway, to reduce the action of testosterone on prostate cancer cells. GNRH agonists or antagonists prevents the release of LH, FSH and ACTH from pituitary gland.
Then come the cytochrome 17P inhibitors that prevent the release of testosterone from testis and adrenal gland. And finally there are androgen receptor blockers that prevents the binding of testosterone to prostate cancer cells, thereby preventing it's action.
Another method for androgen deprivation is surgical castration in which both testes are removed. Unlike medical constration it is a one time procedure.
CancerBro is also active on most social media channels. Follow him to get rich and authoritative content related to cancer awareness, risk factors, symptoms, diagnosis, treatment, etc.
Facebook - https://www.facebook.com/officialcancerbro/
Instagram - https://www.instagram.com/official_cancerbro/
Twitter - https://twitter.com/cancer_bro/
Website - http://www.cancerbro.com/