Does Ibuprofen Really Cause Male Infertility? A study published Monday linked ibuprofen use to infertility issues in young men. The journal Proceedings of the National Academy of Sciences revealed a hormone condition in a sample group of young male athletes who took 600mg doses twice a day for two weeks. Common brand names for ibuprofen are Advil and Motrin. Research previously investigated the affects of painkillers during pregnancy and found mild effects on the testicles of male babies Kevin McEleny, PhD, British Fertility Society (WebMD)